PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/117/ligand/CHEMBL554176
PDB ID	2y5h
Variant Type	IA227L
Ligand ID (ChEMBL ID)	CHEMBL554176
Ligand Similarity* to the one in the experimentally obtained structure of the 2y5h complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.732026
Binding Affinity	Conformer 1: -4.8 Kcal/Mol Conformer 2: -4.8 Kcal/Mol Conformer 3: -4.5 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -4.6 Kcal/Mol