PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/178/ligand/CHEMBL28722
PDB ID	2pog
Variant Type	MA388T
Ligand ID (ChEMBL ID)	CHEMBL28722
Ligand Similarity* to the one in the experimentally obtained structure of the 2pog complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.707965
Binding Affinity	Conformer 1: -7.9 Kcal/Mol Conformer 2: -7.8 Kcal/Mol Conformer 3: -7.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.4 Kcal/Mol