PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/181/ligand/CHEMBL491588
PDB ID	2pog
Variant Type	RA394S
Ligand ID (ChEMBL ID)	CHEMBL491588
Ligand Similarity* to the one in the experimentally obtained structure of the 2pog complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.630435
Binding Affinity	Conformer 1: -8.5 Kcal/Mol Conformer 2: -7.9 Kcal/Mol Conformer 3: -7.3 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -7.3 Kcal/Mol