PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/214/ligand/CHEMBL1898153
PDB ID	4crc
Variant Type	AA190T
Ligand ID (ChEMBL ID)	CHEMBL1898153
Ligand Similarity* to the one in the experimentally obtained structure of the 4crc complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.711111
Binding Affinity	Conformer 1: -5.5 Kcal/Mol Conformer 2: -5.3 Kcal/Mol Conformer 3: -5.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.7 Kcal/Mol