PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/286/ligand/CHEMBL532627
PDB ID	5a7b
Variant Type	TA150K
Ligand ID (ChEMBL ID)	CHEMBL532627
Ligand Similarity* to the one in the experimentally obtained structure of the 5a7b complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.62766
Binding Affinity	Conformer 1: -5.4 Kcal/Mol Conformer 2: -5.3 Kcal/Mol Conformer 3: -5.1 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -4.1 Kcal/Mol