PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/335/ligand/CHEMBL1331618
PDB ID	5a7b
Variant Type	RA202C
Ligand ID (ChEMBL ID)	CHEMBL1331618
Ligand Similarity* to the one in the experimentally obtained structure of the 5a7b complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.625
Binding Affinity	Conformer 1: -7.2 Kcal/Mol Conformer 2: -7.1 Kcal/Mol Conformer 3: -6.9 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -7.6 Kcal/Mol