PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/402/ligand/CHEMBL1779587
PDB ID	3b27
Variant Type	IA59V
Ligand ID (ChEMBL ID)	CHEMBL1779587
Ligand Similarity* to the one in the experimentally obtained structure of the 3b27 complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.802548
Binding Affinity	Conformer 1: -8.5 Kcal/Mol Conformer 2: -7.6 Kcal/Mol Conformer 3: -7.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -8.6 Kcal/Mol