PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/448/ligand/CHEMBL1544737
PDB ID	3b5r
Variant Type	AA748D
Ligand ID (ChEMBL ID)	CHEMBL1544737
Ligand Similarity* to the one in the experimentally obtained structure of the 3b5r complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.603604
Binding Affinity	Conformer 1: -4.2 Kcal/Mol Conformer 2: -4.2 Kcal/Mol Conformer 3: -4.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -4.0 Kcal/Mol