PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/470/ligand/CHEMBL3546325
PDB ID	3b5r
Variant Type	IA869M
Ligand ID (ChEMBL ID)	CHEMBL3546325
Ligand Similarity* to the one in the experimentally obtained structure of the 3b5r complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.618644
Binding Affinity	Conformer 1: -5.9 Kcal/Mol Conformer 2: -5.1 Kcal/Mol Conformer 3: -5.1 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.0 Kcal/Mol