PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/511/ligand/CHEMBL463577
PDB ID	2c3i
Variant Type	EB121D
Ligand ID (ChEMBL ID)	CHEMBL463577
Ligand Similarity* to the one in the experimentally obtained structure of the 2c3i complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.606838
Binding Affinity	Conformer 1: -11.9 Kcal/Mol Conformer 2: -11.2 Kcal/Mol Conformer 3: -11.1 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -11.5 Kcal/Mol