PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/537/ligand/CHEMBL2159212
PDB ID	4e5w
Variant Type	SA961L
Ligand ID (ChEMBL ID)	CHEMBL2159212
Ligand Similarity* to the one in the experimentally obtained structure of the 4e5w complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.818182
Binding Affinity	Conformer 1: -7.9 Kcal/Mol Conformer 2: -7.7 Kcal/Mol Conformer 3: -7.7 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.4 Kcal/Mol