PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/650/ligand/CHEMBL3109540
PDB ID	3udh
Variant Type	GA230S
Ligand ID (ChEMBL ID)	CHEMBL3109540
Ligand Similarity* to the one in the experimentally obtained structure of the 3udh complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.692308
Binding Affinity	Conformer 1: -8.3 Kcal/Mol Conformer 2: -8.2 Kcal/Mol Conformer 3: -7.7 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -8.1 Kcal/Mol