PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/658/ligand/CHEMBL3298291
PDB ID	4m0y
Variant Type	QA420K
Ligand ID (ChEMBL ID)	CHEMBL3298291
Ligand Similarity* to the one in the experimentally obtained structure of the 4m0y complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.704846
Binding Affinity	Conformer 1: -7.8 Kcal/Mol Conformer 2: -7.5 Kcal/Mol Conformer 3: -7.5 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -8.5 Kcal/Mol