PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/667/ligand/CHEMBL3457708
PDB ID	4m0y
Variant Type	DA445E
Ligand ID (ChEMBL ID)	CHEMBL3457708
Ligand Similarity* to the one in the experimentally obtained structure of the 4m0y complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.618056
Binding Affinity	Conformer 1: -5.9 Kcal/Mol Conformer 2: -5.9 Kcal/Mol Conformer 3: -5.6 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.7 Kcal/Mol