PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/670/ligand/CHEMBL1622581
PDB ID	4dli
Variant Type	PA191S
Ligand ID (ChEMBL ID)	CHEMBL1622581
Ligand Similarity* to the one in the experimentally obtained structure of the 4dli complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.906977
Binding Affinity	Conformer 1: -5.7 Kcal/Mol Conformer 2: -5.7 Kcal/Mol Conformer 3: -5.7 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.0 Kcal/Mol