PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/671/ligand/CHEMBL3481744
PDB ID	4dli
Variant Type	EA192Q
Ligand ID (ChEMBL ID)	CHEMBL3481744
Ligand Similarity* to the one in the experimentally obtained structure of the 4dli complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.63964
Binding Affinity	Conformer 1: -5.8 Kcal/Mol Conformer 2: -5.6 Kcal/Mol Conformer 3: -5.6 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.4 Kcal/Mol