PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/673/ligand/CHEMBL16031
PDB ID	4dli
Variant Type	VA239F
Ligand ID (ChEMBL ID)	CHEMBL16031
Ligand Similarity* to the one in the experimentally obtained structure of the 4dli complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.626168
Binding Affinity	Conformer 1: -5.7 Kcal/Mol Conformer 2: -5.6 Kcal/Mol Conformer 3: -5.5 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -5.8 Kcal/Mol