PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/674/ligand/CHEMBL258792
PDB ID	4dli
Variant Type	VA239I
Ligand ID (ChEMBL ID)	CHEMBL258792
Ligand Similarity* to the one in the experimentally obtained structure of the 4dli complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.608
Binding Affinity	Conformer 1: -7.3 Kcal/Mol Conformer 2: -7.3 Kcal/Mol Conformer 3: -7.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -6.9 Kcal/Mol