PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/93/ligand/CHEMBL3085925
PDB ID	2y5h
Variant Type	DA100H
Ligand ID (ChEMBL ID)	CHEMBL3085925
Ligand Similarity* to the one in the experimentally obtained structure of the 2y5h complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.625
Binding Affinity	Conformer 1: -8.3 Kcal/Mol Conformer 2: -8.2 Kcal/Mol Conformer 3: -8.2 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -7.7 Kcal/Mol