PSnpBind - Pocket SNPs effect on protein-ligand binding affinity

GUID	https://w3id.org/psnpbind/variant/94/ligand/CHEMBL2448599
PDB ID	2y5h
Variant Type	DA102N
Ligand ID (ChEMBL ID)	CHEMBL2448599
Ligand Similarity* to the one in the experimentally obtained structure of the 2y5h complex * Tanimoto similarity obtained from the comparison of the FP2 fingerprint of the ligands, calculated using OpenBabel	0.683544
Binding Affinity	Conformer 1: -9.6 Kcal/Mol Conformer 2: -9.5 Kcal/Mol Conformer 3: -9.3 Kcal/Mol
Binding Affiniy against the Wild-type protein
WT	Conformer 1: -8.9 Kcal/Mol